NFL Week 5 Odds, Picks: Expert Predictions, Survivor Picks, Best Bets, Teasers & More

Week 5 of the 2022 NFL regular season is full of storylines. Daniel Jones and Co. are in London as the Giants look to record an upset win over Aaron Rodgers and the Packers, Patriots rookie quarterback Bailey Zappé gets a chance to wow the home fans in his first career start against a porous Lions defense and Cooper Rush and the Cowboys have a chance to build on their hot start with a win over the defending Super Bowl champion Rams in LA

As we do every week, we’ve collected all the best picks and gambling content from and SportsLine and put them in one place, so you can get picks against the spread from our CBS Sports experts, as well as additional feature content for each game, including games from SportsLine’s top experts and the SportsLine projection model, best bets from our staff, survivor picks and more. Ready? Let’s jump!

All NFL odds via Caesars Sportsbook.

What choices can you make with confidence in week 5? And which Super Bowl contender falls hard? Visit SportsLine as its amazing model simulates every NFL play 10,000 times and is almost $7,000 for $100 players in the NFL’s highest-rated picks since its inception.

San Francisco 49ers at Carolina Panthers

Time: Sunday, 4:05 PM ET (CBS), streaming on Paramount+ (click here)
open: 49ers -3.5

Featured game | Carolina Panthers vs. San Francisco 49ers

“The Carolina Panthers are the most unwatchable team in the NFL. If the ratings aren’t a thing yet, they should be, and the Panthers will be 32nd for four straight weeks. The 49ers should stomp on Carolina – the only concern is how San Francisco’s offensive line handles a good Panthers pass rush. Can Jimmy Garoppolo score 21 points? I say yes, which means the Niners win this one and they’ll probably get covered with the way the defense is playing right now.”

CBS Sports senior analyst and Pick Six podcast host Will Brinson breaks down Carolina this week. To read his breakdown of every game this weekend and his best bets, click here.

Philadelphia Eagles at Arizona Cardinals

Time: Sunday, 4:25 PM ET (Fox), stream on fuboTV (try for free)
open: Cardinals -3

Featured game | Arizona Cardinals vs. Philadelphia Eagles

“The Eagles are one of the best teams in the NFL this season, and they’ve covered each of their last three games after falling short in the season opener against the Detroit Lions. I’ve made them my best bet for coverage each of the last two weeks, so why stop now? The Eagles look like a complete team to me. Jaylen Hurts and the offense made the headlines — and I can see why. The Eagles lead the NFL in “big plays” this season with 36. In case you’re wondering, “big plays” are punts of at least 10 yards and passes of at least 20 yards.

The Eagles have run 184 offensive lead plays this season, which is the most in the NFL, while the Cardinals have run 13 offensive lead plays this season, which is the worst in the NFL. The Cardinals defense has been interesting to watch as they blitz at the highest rate in the NFL (41%) but allow a 125.8 passer rating blitzed, which ranks 29th in the NFL. Um.

Arizona doesn’t really have home field advantage, as the Cardinals have lost seven straight home games — the longest such streak in the NFL. But here’s the key stat: The Cards also failed to cover all seven of those home games.”

CBS Sports’ Jordan Dayani is in Philly again this week. To read his Week 5 picks column, click here.

Dallas Cowboys at Los Angeles Rams

Time: Sunday, 4:25 PM ET (Fox), stream on fuboTV (try for free)
open: Aries -5.5

Featured game | Los Angeles Rams vs. Dallas Cowboys

“As much as I want to talk here about how the Cowboys are only good because of Cooper Rush, I’m not going to because it’s not entirely true. The Cowboys are 3-1 right now because their defense is annihilation: They can stop the run, they can stop the pass, and they’re extremely good at embarrassing opposing quarterbacks.

The Cowboys have totaled 15 sacks this season, the second most in the NFL. On the other hand, the Rams’ offensive line has been loaded all year, making the first four weeks of the season a nightmare for Matthew Stafford.

If you saw what happened to Stafford in Week 1 — he was sacked seven times against the Bills — then you got a taste of what could happen to him this week. If you saw what happened to Matthew Stafford on Monday night — he was sacked seven times against the 49ers — then you got a taste of what could happen to him this week. Stafford has been sacked 16 times this season, which is second-most in the NFL, and based on what I’ve seen of the Cowboys’ defense, they could double that total.

The problem for the Rams is that they almost never win, Stafford gets sacked two or more times a game. In Stafford’s 22 regular-season games with the team, the Rams are 11-1 when he’s sacked once or less, but just 3-6 when he’s sacked multiple times. Basically, the Rams have a hard time winning when Stafford is beat.

The other thing about the Cowboys defense is that nobody can score on them. The Cowboys have yet to give up 20 points in a game this year, which is impressive considering they’ve already faced quarterbacks like Joe Burrow and Tom Brady.

Ever since Dak Prescott went down, the Cowboys’ formula for winning games has been pretty simple: Play great defense and pray Cooper Rush doesn’t make mistakes on offense. Well, the prayers are apparently working because Rush has no interceptions in four weeks. I have no idea if the Cowboys are going to stick with Rush for another week or hand the offense over to Dak Prescott, but I don’t care, I’ll take them no matter what.”

CBS Sports NFL pundit John Breach will ride with “America’s Team” this week. To read his top picks for Week 5, click here.

Cincinnati Bengals at Baltimore Ravens

Time: Sunday, 8:20 PM ET (NBC), stream on fuboTV (try for free)
open: Ravens -2.5

Featured game | Baltimore Ravens vs. Cincinnati Bengals

Before making any Bengals vs. Ravens picks or any other NFL predictions, you need to see which side Mike Tierney is on. A veteran sports journalist whose work appears regularly in the New York Times and Los Angeles Times, Mike Tierney has covered the NFL for decades and covered seven Super Bowls. Over the past four seasons, Mike is 232-204 ATS in the NFL. Additionally, Tierney is 33-14-1 in his last 48 picks involving the Ravens, returning $1,750. Anyone who followed him is way up there.

We can tell you he’s under the total, but to see his pick against the spread for this matchup, head over to SportsLine.

Las Vegas Raiders at Kansas City Chiefs

Time: Monday, 8:15 PM ET (ESPN), stream on fuboTV (try for free)
open: Bosses -6

Featured game | Kansas City Chiefs vs. Las Vegas Raiders

SportsLine pundit Larry Hartstein is 427-344 all-time on NFL sides (plus $3,764 for $100 players), including 394-330 against the spread coming into the 2022 season. On top of that, Hartstein is 24-10 in his last 34 picks featuring the Chiefs, returning $1,280, so you’ll definitely want to see where he leans on Monday night. To see his picks for Chiefs-Raiders, go to SportsLine.

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