Ohio State vs Northwestern Prediction Odds: 2022 Week 10 College Football Picks Best Bets From Proven Model

The No. 2 Ohio State Buckeyes will be on the lookout for an upset Saturday when they travel to face the struggling Northwestern Wildcats in a Big Ten game. Last week, the Buckeyes (8-0, 5-0) trailed early in the fourth quarter against No. 13 Penn State, but rallied late for a 44-31 victory to remain undefeated. They now turn their attention to the struggling Wildcats (1-7, 1-4), who fell 33-13 to Iowa last week and are looking for their first win since a 31-28 Week 1 triumph over Nebraska.

Kickoff is set for noon ET from Northwestern’s Ryan Field. Caesars Sportsbook lists the Buckeyes as a 38-point favorite and the over/under for total points scored is 55.5 in the latest Ohio State vs. Northwestern odds. Before locking in your Northwestern vs. Ohio State picks, you should check out the college football predictions and betting tips from SportsLine’s advanced computer model.

The SportsLine projection model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a staggering profit of nearly $3,000 on $100 players in the highest-rated college football picks against the spread. Anyone who has followed him has seen tremendous returns.

The model has now turned to Ohio State vs. Northwestern and has locked in its CFB picks and predictions. You can head over to SportsLine now to see the model selection. Here are some college football odds and betting lines for Northwestern vs. Ohio State:

  • Ohio State vs. Northwestern Point Spread: Ohio State -38
  • Ohio State vs. Northwestern Over/Under Total Points: 55.5
  • NU: The Wildcats have covered the spread in three of their last five conference games as a double-digit underdog.
  • OSU: The road team is 5-1 against the spread in the last six meetings in this rivalry.
  • Ohio State vs. Northwestern Picks: See SportsLine picks

Why Ohio State Can Cover

When the Buckeyes are in rhythm offensively, it often seems like they can score almost as much as they want, especially against weaker opponents. They average 49 points per game, which ranks 4th nationally and could easily be higher if it weren’t for numerous blowout second halves in which the reserves got significant playing time. What’s more, two weeks ago they scored 54 on a stout Iowa defense that allowed just 15.6 points per game.

Heisman candidate CJ Stroud picked apart opposing defensive units with incredible efficiency. The junior has completed 70.3 percent of his passes for 2,377 yards and 29 touchdowns against four interceptions. The Buckeyes should be motivated to stay sharp as they prepare for the end of the season, which includes a visit to an explosive and upset Maryland club, followed by a matchup with Michigan that will likely be for a spot in the conference title game and could serve as a CFP bid eliminator.

Why Northwester can cover

Although the Wildcats have struggled to produce consistently on offense, they have seen a spark in their last two games after making a quarterback change. Sophomore Brendan Sullivan was selected to replace starter Ryan Hilinski and the Wildcats improved their scoring. Sullivan is an athletic dual threat who can make plays with his feet, and he presents another dynamic for opposing teams to worry about. Hilinski, the South Carolina transfer, is more of a classic pocket passer who struggled on tough passes.

Sullivan took over two weeks ago against Maryland and helped produce the team’s highest point total since its season-opening win over Nebraska. In the 31-24 loss, he threw for 143 yards and a touchdown while also rushing for 53 yards and another score. Last week against Iowa, he completed 23 of 30 passes for 159 yards with two touchdowns and one interception. But the Wildcats were held to 18 rushing yards in the 33-13 loss.

How to make Northwestern vs. Ohio State picks

SportsLine’s model leans on the total, projecting a combined 57 points. The model also says that one side of the distribution occurs in over 60% of the simulations. You can only see CFB models of the model in SportsLine.

So who wins Ohio State vs. Northwestern? And which side of the spread is hit in over 60% of the simulations? Visit SportsLine now to see which side of the spread you should jump on, everyone from the model that crushed your college football picks, and find out.

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