Ohio State vs. Notre Dame odds, line: 2022 college football picks, Week 1 predictions by model at 45-32 series

Ohio State quarterback C.J. Stroud can cement his status as the Heisman Trophy favorite when he and the No. 2 Ohio State Buckeyes take on the No. 5 Notre Dame Fighting Irish in a matchup Saturday at Ohio Stadium in Columbus. The 6-foot-3, 218-pound Stroud finished fourth in Heisman Trophy voting last season after earning Big Ten Offensive Player of the Year honors. He enters the season as a +200 favorite in the Heisman Trophy odds, ahead of last year’s winner, Alabama quarterback Bryce Young (+430). Stroud could make a statement against the Irish in Saturday’s season opener.

Kickoff is 7:30 PM ET. The Buckeyes are 17-point favorites in the latest Ohio State vs. Notre Dame odds from Caesars Sportsbook, while the over/under for total points scored is 58.5. Before making a Notre Dame vs. Ohio State pick, be sure to check out the college football predictions and betting tips from SportsLine’s proven computer model.

The SportsLine projection model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a staggering profit of nearly $3,600 on $100 players in the highest-rated college football picks against the spread. He enters Week 1 of the 2022 college football season 45-32 among all of the top-rated college football spreads and moneyline picks dating back to 2021. Anyone who has followed him has seen a huge returnability.

The model has now set its sights on Ohio State vs. Notre Dame and has just locked in its CFB picks and predictions. You can head over to SportsLine now to see the model selection. Here are some college football odds and betting lines for Notre Dame vs. Ohio State:

  • Ohio State vs. Notre Dame spread: Buckeyes -17
  • Ohio State vs. Notre Dame Over/Under: 58.5 points
  • Ohio State vs. Notre Dame money line: Buckeyes -800, Fighting Irish +550
  • OHST: Stroud finished second in the nation in pitching efficiency rating (186.6) last year.
  • ND: The Irish led the nation in fumble recoveries (19) last season.
  • Ohio State vs. Notre Dame picks: See picks at SportsLine

Featured game | Ohio State Buckeyes vs. Notre Dame Fighting Irish

Why Ohio State Can Cover

Stroud has one of the best receivers in the country in Jackson Smith-Njigba to work with. The 6-foot-1, 200-pound junior from Rockwall, Texas, set a Big Ten record with 1,606 receiving yards last season. He also had an Ohio State record 95 receptions and finished the season with five consecutive 100-yard games.

Also, the Buckeyes are dominant at home. In their last 30 games at Ohio Stadium, they are 29-1 with an average score of 49-18. That includes a 9-1 record against ranked teams in which the final score is an average of 41-22.

Why Notre Dame can cover

Notre Dame has arguably the best tight end in the country in Michael Meyer. The 6-foot-4, 265-pound junior already holds the school records for receptions by a tight end in a season (71 in 2021) and touchdowns by a tight end in a season (seven in ’21). He enters 2022 as a member of the Associated Press Preseason Second Team All-America.

In addition, the Irish added a key member in the sophomore in the offseason in safety Brandon Joseph. A transfer from Northwestern, Joseph is coming off two All-America seasons with the Wildcats. He has nine interceptions over the past two years, tied for the most by any player in the FBS, including a Big Ten-leading six in 2020.

How to make Notre Dame vs. Ohio State picks

SportsLine’s model leans on the total, projecting 59 combined points. The model also says that one side of the distribution occurs in more than 60% of the simulations. You can see the model selection only in SportsLine.

So who wins Ohio State vs. Notre Dame? And which side of the spread is hit in more than 60% of the simulations? Visit SportsLine now to find out which side of the spread you should jump on, all from the model that crushed your college football picks, and find out.

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