One in every 500 men can carry an extra sex chromosome (most without knowing it)

At most one in every 500 men can carry an extra sex chromosome – either X or Y – but very few are likely to know about it, a new study shows.

The study, published June 9 in the journal Genetics in medicine (opens in a new tab), includes data from more than 207,000 men who provided information to the UK Biobank, a repository of genetic and health data from half a million participants in the UK. Usually men wear one X- and one Y-shaped sex chromosome in each of their cells, but among the study participants were 213 men who carried an extra X chromosome and 143 had an extra Y.

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