White Sox vs. Guardians Odds Prediction Line: 2022 MLB Picks Sunday August 21 Best Bets From Proven Model

The Cleveland Guardians host the Chicago White Sox for a matinee game on Sunday. The game is the finale of a three-game weekend at Progressive Field. Sunday’s game is also the final game between the AL Central rivals in Cleveland this season. Dylan Cease takes the mound for Chicago against Aaron Civale for Cleveland.

Game one is at 12:05 PM ET in Cleveland. Caesars Sportsbook lists Chicago as a -125 favorite (risk $125 to win $100) on the moneyline, while the over/under, or total number of runs Vegas thinks will score, is 7.5 in the latest odds at White Sox vs. Guardians. Before picking the Guardians vs. White Sox, be sure to check out the latest MLB predictions and betting tips from the SportsLine Projection Model.

The SportsLine projection model simulates every MLB game 10,000 times and is 300-260 on MLB’s top-rated money lines since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of the top three bets to win all of last season. Everyone who has followed him has seen profitable returns.

Now, the model has set its sights on the Guardians vs. White Sox and revealed its preferred picks and predictions. You can go to SportsLine to see all the MLB model picks. Here are some MLB odds and trends for the White Sox vs. Guardians:

  • White Sox vs. Guardians money line: White Sox -125, Guardians +105
  • White Sox vs. Guardians Over/Under: 7.5 runs
  • White Sox vs. Guardians run line: White Sox -1.5 (+135)
  • CHW: The White Sox are 29-24 in day games
  • CLE: The Rangers are 30-24 in day games
  • White Sox vs. Guardians picks: See SportsLine picks

Featured game | Cleveland Guardians vs. Chicago White Sox

Why you should support the White Sox

Chicago’s projection is bolstered by the presence of Dylann Seaz as the team’s expected starting pitcher. Cease is having the best season of his career, and the 26-year-old is an American League Cy Young candidate. He has a 2.09 ERA on the season, and Cease leads the AL with 11.98 strikeouts per nine innings. Opponents have a .602 OPS against Cease, and he has a 2.12 ERA in three starts against Cleveland in 2022.

Cease’s season-long numbers have been great, but he’s been even better recently, including a recent 14-start streak in which he allowed one earned run or less in every outing. Cease has a 0.93 ERA since May 29, and he owns a 1.34 ERA on the road this season. Behind him, Chicago has an above-average bullpen that averages more than one strikeout per inning with a top-five mark in the AL in home run percentage allowed.

Why you should support the Guardians

Cleveland’s offense leads the American League in strikeouts, providing a high baseline in run production. Keepers are in the top four in the AL in hits, doubles, triples, stolen bases and batting average, and Cleveland is above the AL average in hitting percentage, OPS, on-base percentage and runs scored.

On the run prevention side, the Guardians rely on Aaron Sivale, who has been performing well in recent days. After a rough start in 2022, Civale has a 2.97 ERA over his last eight starts, allowing a .634 OPS over that stretch. Sivale has a 2.00 ERA over his last four outings, and his numbers have been much better at home than on the road this season. Cleveland’s bullpen is also pretty good, ranking in the AL’s top five in ERA and wins above replacement, and the Guardians are averaging more than a strikeout per inning and more than three strikeouts per walk.

How to make Guardians vs. White Sox picks

SportsLine’s model leans on the total, predicting 7.9 combined draws and saying that one side of the money line has all the value. You can pick up the select MLB model only at SportsLine.

So who wins White Sox vs. Guardians? And which country has all the value? Visit SportsLine now to find out which side you should jump on, all from the model who crushed his MLB picks, and find out.

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